Logopenic Primary Progressive Aphasia
Based on Marshall et al., 2018
This PPA variant has several synonyms:
- Language-variant Alzheimer’s disease
- Logopenic variant of PPA
“Logopenic PPA” ≠ “Alzheimer's amnesic variant” which has been evolving for 3 years and which is starting to show language disorders!
It is important to clearly understand that logopenic PPA is a variant of PPA, which means that the patient’s first and main complaint is an evolving language deficit. Therefore, a patient diagnosed with a classic amnestic Alzheimer’s disease who shows language difficulties after a few years is not considered a patient with logopenic PPA.
In this variant, people mainly notice a word retrieval problem in spontaneous speech.
Diagnostic features |
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Must be present: |
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At least three features among the following: |
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Diagnostic features based on Gorno-Tempini et al., 2011
Videos courtesy of Dr Marilu Gorno-Tempini's team at
University of San Francisco (California), Memory and Aging Center
Other signs and symptoms often associated with logopenic PPA:
- Isolation, anxiety and depression
- Irritability
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In more severe cases:
- Memory impairment, because in 86% of logopenic PPA cases, the underlying pathology is Alzheimer’s disease (Bergeron et al., 2018, Annals of Neurology)
- Calculation impairment
- Apperceptive visual agnosia (incapacity to recognize, copy or match simple shapes).
- Possible perioral myoclonia
Testimonial
Mrs Simard’s experience with the logopenic variant of PPA
Resources:
- Association des proches aidants de la Capitale-Nationale: https://www.apacn.org/
- Baluchon Alzheimer: https://baluchonalzheimer.com/
- Monastère des Augustines: https://monastere.ca/en
- Alzheimer’s Society: https://alzheimer.ca/federationquebecoise/en
- AQDR : https://www.aqdr.org/
- The Association for Frontotemporal Degeneration: https://www.theaftd.org